By N. Torn. Franklin University.

The composition of capsules with diclofenac sodium was formulated under the supervision of Associate Professor Sichkar A order aristocort 10mg mastercard allergy treatment kerala. The pharmacotechnological properties analysis of the test substance diclofenac sodium had shown that the substance had poor flowability buy 10 mg aristocort with amex allergy medicine pregnancy safe, hence it was concluded that direct filling of powder into capsules was not possible. It is predetermined application of special inactive ingredients for improvement pharmacotechnological characteristics. Capsule mixtures on the basis of substance were investigated with combinations of lactose monohydrate, potato starch, croscarmellose sodium, aerosil, talc, magnesium stearate in different correlations. Since diclofenac sodium is poorly soluble in water, starch and croscarmellose sodium were used to increase penetration of the stomach liquid into encapsulated mass in capsules. Aerosil and magnesium stearate reduces the friction between particles of the composition and the surface friction between particles of the composition and the equipment surface. It was established that lactose monohydrate and aerosil have more influence on flowability of the active substance. Auxiliary ingredients and technology of capsules with diclofenac sodium for manufacture in Iraq were chosen as a result of research. In the pharmaceutical industry, project management is the key to addressing the unique regulatory, compliance and quality related needs of the industry. The process of clinical research and drug development, coupled with the critical issue of time to market, can capitalize on project management techniques to effectively apply scheduling, risk management, and comprehensive quality assurance and control to the process of bringing a drug to market in a cost-efficient way. Project management is a discipline that can be applied to all industries, regardless of the product or service they are designed to deliver. Beyond its basic application across various industries, project management has tremendous value when effectively implemented to significantly increase the success of the product or service being delivered. The pharmaceutical industry has encountered major shifts in recent years, both within the industry and in its external environment. Some of the factors responsible for this shift include the rising cost of healthcare due to an aging population, the increase in rigorous regulatory requirements, and company mergers within the industry. These factors have led to an increased need for restructuring, cost reduction, and culture change projects. Every industry has different ―stress points‖—those points that are most critical to the specific product or service being delivered. Depending on the industry, one (sometimes more) of these stress points directly affects that industry‘s profit, thereby making that point absolutely critical to the success of the product, and the company delivering it. It becomes, therefore, a priority in the set of processes involved in producing the product. Specifically in the pharmaceutical industry, there has never been a tougher time to be involved in drug development. In recent years, the market has become much 400 more competitive, and the political, regulatory, social and economic pressures have become much more intense. Also, each year at least one drug company experiences a recall of one of their drugs, lawsuits from their customers or lawsuits from their competitors. Poor quality in this industry can literally be a matter of life and death, in its worse cases. Being the first to bring a product to market is also critical, though the course of drug development is unpredictable. Because of the risks involved in the pharmaceutical industry, due diligence is of the utmost importance in terms of quality control measures. So these competing priorities quality and time to market must be well managed through careful process in order to reduce the risks inherent in this industry. Another current challenge for pharmaceutical companies is the pressure they are under to increase their productivity, as the number of new products reaching the market has been on the decline over the past few years.

Editorial comments • Do not coadminister with allopurinol as the combination may lead to severe hypersensitivity vasculitis aristocort 10 mg low cost allergy qld. Mechanism of action: Blocks acetylcholine effects at muscarinic receptors throughout the body generic aristocort 15mg with amex allergy treatment by baba ramdev. Adverse reactions • Common: dry mouth, blurred vision (decreased accommoda- tion), drowsiness, tachycardia, urinary hesitancy, dry skin, con- stipation. Parameters to monitor • Signs and symptoms of severe toxicity: tachycardia, supraven- tricular arrythmias, delirium, seizures, agitation, hyperthermia. Mechanism of action: Inhibits migration of polymorphonuclear leukocytes; stabilizes lysomal membranes; inhibits production of products of arachidonic acid cascade. These should be individualized according to the disease being treated and the response of the patient. Contraindications: Systemic use: fungal, viral, or bacterial infec- tions, Cushing’s syndrome. Topical use: hypersensitivity to cor- ticosteroids, markedly impaired circulation, occlusive dressing if primary skin infection is present, monotherapy in primary bac- terial infections, eg, impetigo, cellulitis, rosacea, ophthalmic use, plaque psoriasis (widespread). Warnings/precautions • Use with caution in patients with the following conditions: diabetes mellitus, cardiovascular disease, hypertension, throm- bophlebitis, renal or hepatic insufficiency. Topical agent: Use with caution in patients with primary skin infections and those receiving other immunosuppressant drugs. When every-other-day therapy is initiated, twice the daily dose should be administered on alternate days in the morning. Adverse reactions • Common: dyspepsia, appetite stimulation, insomnia, anxiety, fluid retension, cushinoid facies. Children: Growth suppression, pseudotumor cerebri (reversible papilledema, visual loss, nerve paralysis [abducens or oculomotor]), vascular bone necrosis, pan- creatitis. Editorial comments: Corticoid treatment remains challeng- ing for clinicians due to commonly occurring short-term and long-term side effects. The agents produce accelerated bone resorption as well as decreased bone formation, result- ing in overall bone loss with chronic use. Ongoing monitor- ing is suggested and treatment with bisphosphonates or calcitonin is suggested when decreased bone mineral density occurs. Mechanism of action: Competitive blocker of β-adrenergic receptors in heart, blood vessels, and eyes. If necessary to dis- continue, taper as follows: Reduce dose and reassess after 1–2 weeks. Advice to patient • Avoid driving and other activities requiring mental alertness or that are potentially dangerous until response to drug is known. Clinically important drug interactions • Drugs that increase effects/toxicity of β blockers: reserpine, bretylium, calcium channel blockers. If hypotension occurs despite correction of bradycardia, administer vasopressor (norephinephrine, dopamine, or dobuta- mine). Stop therapy and administer large doses of β-adrenergic bronchodilator, eg, albuterol, terbutaline, or amino- phylline. Some advocate discontinuing the drug 48 hours before surgery; others recommend withdrawal for a considerably longer time. These are drugs of first choice for chronic stable angina, used in conjunction with nitroglycerin. Warnings/precautions • Use with caution in patients with the following conditions: epilepsy, hyperthyroidism.

The aim of our research is to study the impact of excipients and parameters production process on quality characteristic solid dosage forms that in its composition containing bed soluble substance buy aristocort 40mg low price allergy symptoms list. The objects of study are generic and original drugs: The objects of study are generic and original drugs:  «Boryzol" and "Rilutek" tablets buy aristocort 40 mg free shipping allergy desensitization, film coated shell that contains in its composition 50 mg of drug substance ryluzol;  «Nimodipine" and "Nimotop" tablets, film coated shell that contains in its composition 30 mg of drug substance nimodipine. Because of the low solubility of the substances ryluzol and nimodipine problem creating acceptable dosage form that characterized by the need to improve 405 the solubility of active pharmaceutical substances and their stable uniform distribution in each tablet. Usually, increasing the solubility of these substances is achieved by adding appropriate excipients of the drugs or using technological methods of physical modifications substances. During the pharmaceutical development of generic drugs "Boryzol" and "Nimodipine" studies on the effect of excipients and process parameters on quality tablets:  influence of excipients on the solubility of substances ryluzol and nimodipine tablets of drugs was researched;  influence of various technological methods of physical modification substances ryluzol and nimodipine on dissolution from solid dosage forms was researched;  influence of excipients on pharmaco-technological properties powders and tablets was researched;  influence of process parameters on dissolution of the substances ryluzol and nimodipine from tablets was researched. The resulting enhanced scientific data make it possible to determine the effect of excipients and process parameters on the quality of generic drugs "Boryzol" and "Nimodipine "controlled during their industrial production, and is the key issue highly efficient pharmaceutical industry generic drugs. They are associated with the use of computers and telecommunications, special equipment, software and hardware, data processing systems. They are also associated with the creation of new learning tools and knowledge preservations, which include electronic textbooks and multimedia; libraries and archives, global and local educational network; information searching and information reference systems. These systems make it possible to provide effective support to the active perception of educational material. The advantage of virtual laboratories is that the student can choose different modes of operation of the program; change the parameters of the objects or processes; observe and analyze results; draw conclusions based on their observations; operate independently of a laboratory in any places, using a computer, tablet or smartphone; perform tasks using the Internet. They provide the conditions for understanding the problems, the study of patterns forming hypotheses based on their subsequent experimental verification. Thus, a lot of opportunities appear for student for research and creative activity that promotes cognitive interest. To effectively enhance learning of students in teaching course "Analytical Chemistry" we have used virtual chemical laboratories that allowed performing 407 experiments to record experimentally obtained data, use reference books, instructions, etc. In conducting laboratory studies of qualitative analysis of experiments and tasks of identifying some inorganic substances, the students performed the task via online portal for virtual laboratory VirtualLab (virtulab. In the "Report" section students completed the relevant sections, fixing the value obtained in the course of the experiment of the measured values, analyzed findings and made appropriate conclusions. As in a real laboratory work, in the virtual one students had to learn research skills, nomination hypotheses and their checking standardization conditions, clear fixation conditions and the experimental results (harvested in laboratory journals or in electronic form), choose the format of presentation of results and then plan an independent research (project). The ability to conduct virtual experiments greatly expanded the list of chemicals that are still traditionally used in laboratory practice and now require special storage usage and also are toxic and poisonous gives the opportunity to work with them during the laboratory sessions. When performing virtual experiments, students were able to work with them; required for a particular experiment equipment and instruments, whose presence in the laboratory can not be thus been able to work out laboratory practice. Students had the opportunity to receive counseling teacher to communicate with each other, discuss issues that arose during the study subjects. In addition, the group uploaded photos and videos of some experiments, additional literature on the subject "Analytical Chemistry" provided links to specialized sites and online virtual lab. Testifying is to bringing of subject of publishing business in the state register of publishers, manufacturers and spreaders of publishing products. Brittain University of Maryland Center for Pharmaceutical Physics Baltimore, Maryland Milford, New Jersey Jennifer B. Dressman Robert Gurny University of Frankfurt Institute of Universite de Geneve Pharmaceutical Technology Geneve, Switzerland Frankfurt, Germany Jeffrey A. Hickey University of Florida College University of North Carolina of Pharmacy School of Pharmacy Gainesville, Florida Chapel Hill, North Carolina Vincent H. Polli Kinam Park GlaxoSmithKline Purdue University Research Triangle Park West Lafayette, Indiana North Carolina Jerome P. Schulman Alexandria, Virginia University of Florida Gainesville, Florida Elizabeth M.